Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial.
Identifieur interne : 000924 ( Main/Exploration ); précédent : 000923; suivant : 000925Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial.
Auteurs : Paolo A. Ascierto [Italie] ; Michele Del Vecchio [Italie] ; Caroline Robert [France] ; Andrzej Mackiewicz [Pologne] ; Vanna Chiarion-Sileni [Italie] ; Ana Arance [Espagne] ; Céleste Lebbé [France] ; Lars Bastholt [Danemark] ; Omid Hamid [États-Unis] ; Piotr Rutkowski [Pologne] ; Catriona Mcneil [Australie] ; Claus Garbe [Allemagne] ; Carmen Loquai [Allemagne] ; Brigitte Dreno [France] ; Luc Thomas [France] ; Jean-Jacques Grob [France] ; Gabriella Liszkay [Hongrie] ; Marta Nyakas [Norvège] ; Ralf Gutzmer [Allemagne] ; Joanna Pikiel [Pologne] ; Florent Grange [France] ; Christoph Hoeller [Autriche] ; Virginia Ferraresi [Italie] ; Michael Smylie [Canada] ; Dirk Schadendorf [Allemagne] ; Laurent Mortier [France] ; Inge Marie Svane [Danemark] ; Delphine Hennicken [États-Unis] ; Anila Qureshi [États-Unis] ; Michele Maio [Italie]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Alanine transaminase (sang), Analyse de l'intention de traiter, Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (effets indésirables), Antinéoplasiques (administration et posologie), Antinéoplasiques (effets indésirables), Colite (), Diarrhée (), Femelle, Humains, Hypophysite (), Mâle, Mélanome (secondaire), Mélanome (traitement médicamenteux), Méthode en double aveugle, Résultat thérapeutique, Sujet âgé, Taux de survie, Études de suivi.
- MESH :
- administration et posologie : Anticorps monoclonaux, Antinéoplasiques.
- effets indésirables : Anticorps monoclonaux, Antinéoplasiques.
- sang : Alanine transaminase.
- secondaire : Mélanome.
- traitement médicamenteux : Mélanome.
- Adulte d'âge moyen, Analyse de l'intention de traiter, Colite, Diarrhée, Femelle, Humains, Hypophysite, Mâle, Méthode en double aveugle, Résultat thérapeutique, Sujet âgé, Taux de survie, Études de suivi.
English descriptors
- KwdEn :
- Aged, Alanine Transaminase (blood), Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (adverse effects), Antineoplastic Agents (administration & dosage), Antineoplastic Agents (adverse effects), Colitis (chemically induced), Diarrhea (chemically induced), Double-Blind Method, Female, Follow-Up Studies, Humans, Hypophysitis (chemically induced), Intention to Treat Analysis, Male, Melanoma (drug therapy), Melanoma (secondary), Middle Aged, Survival Rate, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Antineoplastic Agents.
- chemical , adverse effects : Antibodies, Monoclonal, Antineoplastic Agents.
- chemical , blood : Alanine Transaminase.
- chemically induced : Colitis, Diarrhea, Hypophysitis.
- drug therapy : Melanoma.
- secondary : Melanoma.
- Aged, Double-Blind Method, Female, Follow-Up Studies, Humans, Intention to Treat Analysis, Male, Middle Aged, Survival Rate, Treatment Outcome.
Abstract
A phase 2 trial suggested increased overall survival and increased incidence of treatment-related grade 3-4 adverse events with ipilimumab 10 mg/kg compared with ipilimumab 3 mg/kg in patients with advanced melanoma. We report a phase 3 trial comparing the benefit-risk profile of ipilimumab 10 mg/kg versus 3 mg/kg.
DOI: 10.1016/S1470-2045(17)30231-0
PubMed: 28359784
Affiliations:
- Allemagne, Australie, Autriche, Canada, Danemark, Espagne, France, Hongrie, Italie, Norvège, Pologne, États-Unis
- Bade-Wurtemberg, Basse-Saxe, Californie, Catalogne, Champagne-Ardenne, District de Tübingen, Grand Est, Hauts-de-France, Hongrie centrale, Latium, Lombardie, New Jersey, Nord-Pas-de-Calais, Pays de la Loire, Provence-Alpes-Côte d'Azur, Rhénanie-Palatinat, Vienne (Autriche), Île-de-France, Østlandet
- Barcelone, Budapest, Hanovre, Lille, Marseille, Mayence, Milan, Nantes, Oslo, Paris, Reims, Rome, Tübingen, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
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Le document en format XML
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C" first="Céleste" last="Lebbé">Céleste Lebbé</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP Dermatology CIC Departments, Saint-Louis Hospital, INSERM U976, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP Dermatology CIC Departments, Saint-Louis Hospital, INSERM U976, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bastholt, Lars" sort="Bastholt, Lars" uniqKey="Bastholt L" first="Lars" last="Bastholt">Lars Bastholt</name><affiliation wicri:level="1"><nlm:affiliation>Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Hamid, Omid" sort="Hamid, Omid" uniqKey="Hamid O" first="Omid" last="Hamid">Omid Hamid</name><affiliation wicri:level="2"><nlm:affiliation>The Angeles Clinic and Research Institute, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Angeles Clinic and Research Institute, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Memorial Cancer Center, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Mcneil, Catriona" sort="Mcneil, Catriona" uniqKey="Mcneil C" first="Catriona" last="Mcneil">Catriona Mcneil</name><affiliation wicri:level="1"><nlm:affiliation>Chris O'Brien Lifehouse and Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Melanoma Institute Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chris O'Brien Lifehouse and Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Melanoma Institute Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:affiliation>Eberhard Karls University, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Eberhard Karls University, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dreno">Brigitte Dreno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncodermatology, INSERM Research Unit 892, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oncodermatology, INSERM Research Unit 892, Nantes University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Centre Hospitalier Lyon-Sud, Pierre-Bénite</wicri:regionArea><wicri:noRegion>Pierre-Bénite</wicri:noRegion><wicri:noRegion>Pierre-Bénite</wicri:noRegion></affiliation></author><author><name sortKey="Grob, Jean Jacques" sort="Grob, Jean Jacques" uniqKey="Grob J" first="Jean-Jacques" last="Grob">Jean-Jacques Grob</name><affiliation wicri:level="3"><nlm:affiliation>Hospital de la Timone, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hospital de la Timone, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Oncology, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nyakas, Marta" sort="Nyakas, Marta" uniqKey="Nyakas M" first="Marta" last="Nyakas">Marta Nyakas</name><affiliation wicri:level="3"><nlm:affiliation>Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Pikiel, Joanna" sort="Pikiel, Joanna" uniqKey="Pikiel J" first="Joanna" last="Pikiel">Joanna Pikiel</name><affiliation wicri:level="1"><nlm:affiliation>Wojewodzkie Centrum Oncologii, Gdańsk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wojewodzkie Centrum Oncologii, Gdańsk</wicri:regionArea><wicri:noRegion>Gdańsk</wicri:noRegion></affiliation></author><author><name sortKey="Grange, Florent" sort="Grange, Florent" uniqKey="Grange F" first="Florent" last="Grange">Florent Grange</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Hoeller, Christoph" sort="Hoeller, Christoph" uniqKey="Hoeller C" first="Christoph" last="Hoeller">Christoph Hoeller</name><affiliation wicri:level="3"><nlm:affiliation>Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Ferraresi, Virginia" sort="Ferraresi, Virginia" uniqKey="Ferraresi V" first="Virginia" last="Ferraresi">Virginia Ferraresi</name><affiliation wicri:level="3"><nlm:affiliation>Istituti Fisioterapici Ospitalieri, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituti Fisioterapici Ospitalieri, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Smylie, Michael" sort="Smylie, Michael" uniqKey="Smylie M" first="Michael" last="Smylie">Michael Smylie</name><affiliation wicri:level="1"><nlm:affiliation>Cross Cancer Institute, Edmonton, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cross Cancer Institute, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Mortier, Laurent" sort="Mortier, Laurent" uniqKey="Mortier L" first="Laurent" last="Mortier">Laurent Mortier</name><affiliation wicri:level="3"><nlm:affiliation>Hôspital Claude Huriez, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôspital Claude Huriez, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Svane, Inge Marie" sort="Svane, Inge Marie" uniqKey="Svane I" first="Inge Marie" last="Svane">Inge Marie Svane</name><affiliation wicri:level="1"><nlm:affiliation>Herlev Hospital, University of Copenhagen, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Herlev Hospital, University of Copenhagen, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Hennicken, Delphine" sort="Hennicken, Delphine" uniqKey="Hennicken D" first="Delphine" last="Hennicken">Delphine Hennicken</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Qureshi, Anila" sort="Qureshi, Anila" uniqKey="Qureshi A" first="Anila" last="Qureshi">Anila Qureshi</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University Hospital of Siena, Istituto Toscano Tumori, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28359784</idno><idno type="pmid">28359784</idno><idno type="doi">10.1016/S1470-2045(17)30231-0</idno><idno type="wicri:Area/PubMed/Corpus">000D14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D14</idno><idno type="wicri:Area/PubMed/Curation">000D11</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D11</idno><idno type="wicri:Area/PubMed/Checkpoint">000D11</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D11</idno><idno type="wicri:Area/Ncbi/Merge">004549</idno><idno type="wicri:Area/Ncbi/Curation">004549</idno><idno type="wicri:Area/Ncbi/Checkpoint">004549</idno><idno type="wicri:Area/Main/Merge">000919</idno><idno type="wicri:Area/Main/Curation">000924</idno><idno type="wicri:Area/Main/Exploration">000924</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial.</title><author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><nlm:affiliation>Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy. Electronic address: paolo.ascierto@gmail.com.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto Nazionale Tumori Fondazione Pascale, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Del Vecchio, Michele" sort="Del Vecchio, Michele" uniqKey="Del Vecchio M" first="Michele" last="Del Vecchio">Michele Del Vecchio</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology, National Cancer Institute, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology, National Cancer Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy Cancer Campus Grand Paris, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy Cancer Campus Grand Paris, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Mackiewicz, Andrzej" sort="Mackiewicz, Andrzej" uniqKey="Mackiewicz A" first="Andrzej" last="Mackiewicz">Andrzej Mackiewicz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan Medical University, Poznan, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan Medical University, Poznan</wicri:regionArea><wicri:noRegion>Poznan</wicri:noRegion></affiliation></author><author><name sortKey="Chiarion Sileni, Vanna" sort="Chiarion Sileni, Vanna" uniqKey="Chiarion Sileni V" first="Vanna" last="Chiarion-Sileni">Vanna Chiarion-Sileni</name><affiliation wicri:level="1"><nlm:affiliation>IOV-IRCCS, Melanoma Oncology Unit, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IOV-IRCCS, Melanoma Oncology Unit, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Arance, Ana" sort="Arance, Ana" uniqKey="Arance A" first="Ana" last="Arance">Ana Arance</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi I Sunyer, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP Dermatology CIC Departments, Saint-Louis Hospital, INSERM U976, Université Paris Diderot, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP Dermatology CIC Departments, Saint-Louis Hospital, INSERM U976, Université Paris Diderot, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bastholt, Lars" sort="Bastholt, Lars" uniqKey="Bastholt L" first="Lars" last="Bastholt">Lars Bastholt</name><affiliation wicri:level="1"><nlm:affiliation>Odense University Hospital, Odense, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Odense University Hospital, Odense</wicri:regionArea><wicri:noRegion>Odense</wicri:noRegion></affiliation></author><author><name sortKey="Hamid, Omid" sort="Hamid, Omid" uniqKey="Hamid O" first="Omid" last="Hamid">Omid Hamid</name><affiliation wicri:level="2"><nlm:affiliation>The Angeles Clinic and Research Institute, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Angeles Clinic and Research Institute, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Memorial Cancer Center, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Mcneil, Catriona" sort="Mcneil, Catriona" uniqKey="Mcneil C" first="Catriona" last="Mcneil">Catriona Mcneil</name><affiliation wicri:level="1"><nlm:affiliation>Chris O'Brien Lifehouse and Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Melanoma Institute Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Chris O'Brien Lifehouse and Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Melanoma Institute Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name><affiliation wicri:level="3"><nlm:affiliation>Eberhard Karls University, Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Eberhard Karls University, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dreno">Brigitte Dreno</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncodermatology, INSERM Research Unit 892, Nantes University Hospital, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Oncodermatology, INSERM Research Unit 892, Nantes University Hospital, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Centre Hospitalier Lyon-Sud, Pierre-Bénite</wicri:regionArea><wicri:noRegion>Pierre-Bénite</wicri:noRegion><wicri:noRegion>Pierre-Bénite</wicri:noRegion></affiliation></author><author><name sortKey="Grob, Jean Jacques" sort="Grob, Jean Jacques" uniqKey="Grob J" first="Jean-Jacques" last="Grob">Jean-Jacques Grob</name><affiliation wicri:level="3"><nlm:affiliation>Hospital de la Timone, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hospital de la Timone, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name><affiliation wicri:level="3"><nlm:affiliation>National Institute of Oncology, Budapest, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute of Oncology, Budapest</wicri:regionArea><placeName><settlement type="city">Budapest</settlement><region nuts="2">Hongrie centrale</region></placeName></affiliation></author><author><name sortKey="Nyakas, Marta" sort="Nyakas, Marta" uniqKey="Nyakas M" first="Marta" last="Nyakas">Marta Nyakas</name><affiliation wicri:level="3"><nlm:affiliation>Oslo University Hospital, Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Oslo University Hospital, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Pikiel, Joanna" sort="Pikiel, Joanna" uniqKey="Pikiel J" first="Joanna" last="Pikiel">Joanna Pikiel</name><affiliation wicri:level="1"><nlm:affiliation>Wojewodzkie Centrum Oncologii, Gdańsk, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wojewodzkie Centrum Oncologii, Gdańsk</wicri:regionArea><wicri:noRegion>Gdańsk</wicri:noRegion></affiliation></author><author><name sortKey="Grange, Florent" sort="Grange, Florent" uniqKey="Grange F" first="Florent" last="Grange">Florent Grange</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Reims University Hospital, Reims, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Reims University Hospital, Reims</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Champagne-Ardenne</region><settlement type="city">Reims</settlement></placeName></affiliation></author><author><name sortKey="Hoeller, Christoph" sort="Hoeller, Christoph" uniqKey="Hoeller C" first="Christoph" last="Hoeller">Christoph Hoeller</name><affiliation wicri:level="3"><nlm:affiliation>Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Ferraresi, Virginia" sort="Ferraresi, Virginia" uniqKey="Ferraresi V" first="Virginia" last="Ferraresi">Virginia Ferraresi</name><affiliation wicri:level="3"><nlm:affiliation>Istituti Fisioterapici Ospitalieri, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituti Fisioterapici Ospitalieri, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Smylie, Michael" sort="Smylie, Michael" uniqKey="Smylie M" first="Michael" last="Smylie">Michael Smylie</name><affiliation wicri:level="1"><nlm:affiliation>Cross Cancer Institute, Edmonton, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cross Cancer Institute, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Mortier, Laurent" sort="Mortier, Laurent" uniqKey="Mortier L" first="Laurent" last="Mortier">Laurent Mortier</name><affiliation wicri:level="3"><nlm:affiliation>Hôspital Claude Huriez, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôspital Claude Huriez, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Svane, Inge Marie" sort="Svane, Inge Marie" uniqKey="Svane I" first="Inge Marie" last="Svane">Inge Marie Svane</name><affiliation wicri:level="1"><nlm:affiliation>Herlev Hospital, University of Copenhagen, Herlev, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Herlev Hospital, University of Copenhagen, Herlev</wicri:regionArea><wicri:noRegion>Herlev</wicri:noRegion></affiliation></author><author><name sortKey="Hennicken, Delphine" sort="Hennicken, Delphine" uniqKey="Hennicken D" first="Delphine" last="Hennicken">Delphine Hennicken</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Qureshi, Anila" sort="Qureshi, Anila" uniqKey="Qureshi A" first="Anila" last="Qureshi">Anila Qureshi</name><affiliation wicri:level="2"><nlm:affiliation>Bristol-Myers Squibb, Princeton, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bristol-Myers Squibb, Princeton, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University Hospital of Siena, Istituto Toscano Tumori, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alanine Transaminase (blood)</term><term>Antibodies, Monoclonal (administration & dosage)</term><term>Antibodies, Monoclonal (adverse effects)</term><term>Antineoplastic Agents (administration & dosage)</term><term>Antineoplastic Agents (adverse effects)</term><term>Colitis (chemically induced)</term><term>Diarrhea (chemically induced)</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Hypophysitis (chemically induced)</term><term>Intention to Treat Analysis</term><term>Male</term><term>Melanoma (drug therapy)</term><term>Melanoma (secondary)</term><term>Middle Aged</term><term>Survival Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Alanine transaminase (sang)</term><term>Analyse de l'intention de traiter</term><term>Anticorps monoclonaux (administration et posologie)</term><term>Anticorps monoclonaux (effets indésirables)</term><term>Antinéoplasiques (administration et posologie)</term><term>Antinéoplasiques (effets indésirables)</term><term>Colite ()</term><term>Diarrhée ()</term><term>Femelle</term><term>Humains</term><term>Hypophysite ()</term><term>Mâle</term><term>Mélanome (secondaire)</term><term>Mélanome (traitement médicamenteux)</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Taux de survie</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antineoplastic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Alanine Transaminase</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Colitis</term><term>Diarrhea</term><term>Hypophysitis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antinéoplasiques</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Alanine transaminase</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Melanoma</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Intention to Treat Analysis</term><term>Male</term><term>Middle Aged</term><term>Survival Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de l'intention de traiter</term><term>Colite</term><term>Diarrhée</term><term>Femelle</term><term>Humains</term><term>Hypophysite</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Taux de survie</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A phase 2 trial suggested increased overall survival and increased incidence of treatment-related grade 3-4 adverse events with ipilimumab 10 mg/kg compared with ipilimumab 3 mg/kg in patients with advanced melanoma. We report a phase 3 trial comparing the benefit-risk profile of ipilimumab 10 mg/kg versus 3 mg/kg.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Italie</li><li>Norvège</li><li>Pologne</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>Californie</li><li>Catalogne</li><li>Champagne-Ardenne</li><li>District de Tübingen</li><li>Grand Est</li><li>Hauts-de-France</li><li>Hongrie centrale</li><li>Latium</li><li>Lombardie</li><li>New Jersey</li><li>Nord-Pas-de-Calais</li><li>Pays de la Loire</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhénanie-Palatinat</li><li>Vienne (Autriche)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Barcelone</li><li>Budapest</li><li>Hanovre</li><li>Lille</li><li>Marseille</li><li>Mayence</li><li>Milan</li><li>Nantes</li><li>Oslo</li><li>Paris</li><li>Reims</li><li>Rome</li><li>Tübingen</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name></noRegion><name sortKey="Chiarion Sileni, Vanna" sort="Chiarion Sileni, Vanna" uniqKey="Chiarion Sileni V" first="Vanna" last="Chiarion-Sileni">Vanna Chiarion-Sileni</name><name sortKey="Del Vecchio, Michele" sort="Del Vecchio, Michele" uniqKey="Del Vecchio M" first="Michele" last="Del Vecchio">Michele Del Vecchio</name><name sortKey="Ferraresi, Virginia" sort="Ferraresi, Virginia" uniqKey="Ferraresi V" first="Virginia" last="Ferraresi">Virginia Ferraresi</name><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name></country><country name="France"><noRegion><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name></noRegion><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dreno">Brigitte Dreno</name><name sortKey="Grange, Florent" sort="Grange, Florent" uniqKey="Grange F" first="Florent" last="Grange">Florent Grange</name><name sortKey="Grob, Jean Jacques" sort="Grob, Jean Jacques" uniqKey="Grob J" first="Jean-Jacques" last="Grob">Jean-Jacques Grob</name><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Céleste" last="Lebbé">Céleste Lebbé</name><name sortKey="Mortier, Laurent" sort="Mortier, Laurent" uniqKey="Mortier L" first="Laurent" last="Mortier">Laurent Mortier</name><name sortKey="Thomas, Luc" sort="Thomas, Luc" uniqKey="Thomas L" first="Luc" last="Thomas">Luc Thomas</name></country><country name="Pologne"><noRegion><name sortKey="Mackiewicz, Andrzej" sort="Mackiewicz, Andrzej" uniqKey="Mackiewicz A" first="Andrzej" last="Mackiewicz">Andrzej Mackiewicz</name></noRegion><name sortKey="Pikiel, Joanna" sort="Pikiel, Joanna" uniqKey="Pikiel J" first="Joanna" last="Pikiel">Joanna Pikiel</name><name sortKey="Rutkowski, Piotr" sort="Rutkowski, Piotr" uniqKey="Rutkowski P" first="Piotr" last="Rutkowski">Piotr Rutkowski</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Arance, Ana" sort="Arance, Ana" uniqKey="Arance A" first="Ana" last="Arance">Ana Arance</name></region></country><country name="Danemark"><noRegion><name sortKey="Bastholt, Lars" sort="Bastholt, Lars" uniqKey="Bastholt L" first="Lars" last="Bastholt">Lars Bastholt</name></noRegion><name sortKey="Svane, Inge Marie" sort="Svane, Inge Marie" uniqKey="Svane I" first="Inge Marie" last="Svane">Inge Marie Svane</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Hamid, Omid" sort="Hamid, Omid" uniqKey="Hamid O" first="Omid" last="Hamid">Omid Hamid</name></region><name sortKey="Hennicken, Delphine" sort="Hennicken, Delphine" uniqKey="Hennicken D" first="Delphine" last="Hennicken">Delphine Hennicken</name><name sortKey="Qureshi, Anila" sort="Qureshi, Anila" uniqKey="Qureshi A" first="Anila" last="Qureshi">Anila Qureshi</name></country><country name="Australie"><noRegion><name sortKey="Mcneil, Catriona" sort="Mcneil, Catriona" uniqKey="Mcneil C" first="Catriona" last="Mcneil">Catriona Mcneil</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name></region><name sortKey="Gutzmer, Ralf" sort="Gutzmer, Ralf" uniqKey="Gutzmer R" first="Ralf" last="Gutzmer">Ralf Gutzmer</name><name sortKey="Loquai, Carmen" sort="Loquai, Carmen" uniqKey="Loquai C" first="Carmen" last="Loquai">Carmen Loquai</name><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name></country><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Liszkay, Gabriella" sort="Liszkay, Gabriella" uniqKey="Liszkay G" first="Gabriella" last="Liszkay">Gabriella Liszkay</name></region></country><country name="Norvège"><region name="Østlandet"><name sortKey="Nyakas, Marta" sort="Nyakas, Marta" uniqKey="Nyakas M" first="Marta" last="Nyakas">Marta Nyakas</name></region></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Hoeller, Christoph" sort="Hoeller, Christoph" uniqKey="Hoeller C" first="Christoph" last="Hoeller">Christoph Hoeller</name></region></country><country name="Canada"><noRegion><name sortKey="Smylie, Michael" sort="Smylie, Michael" uniqKey="Smylie M" first="Michael" last="Smylie">Michael Smylie</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28359784" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |